[Cytotoxic effect of the lymphocytes in ischemic heart disease].

Abstract

Coronary patients were shown to have a pool of sensitized killer T cells that produce a cytotoxic effect on target cells loaded with infarcted and intact myocardial antigens and on actomyosin proteins, and evidence of delayed hypersensitivity developing in association with coronary disease. Two kinds of immune shifts were identified with respect to the time of onset of this effect in acute myocardial infarction: in the first case, the appropriate level was exceeded within 2-3 weeks of the disease, and in the second case, within the first days in hospital. The disease tended to take a more severe course in patients with the second type of immune response.

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